IWS1 antibody

Catalog No. ABIN7115537

The Rabbit Polyclonal anti-IWS1 antibody has been validated for WB, ELISA and IP. It is suitable to detect IWS1 in samples from Human, Rat and Mouse.

Quick Overview for IWS1 antibody (ABIN7115537)

Target: IWS1 (IWS1 Homolog (IWS1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IWS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-IWS1 Antibody

Purpose: IWS1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: IWS1 homolog

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IWS1

Target: IWS1 (IWS1 Homolog (IWS1))

Alternative Name: IWS1

Background:

Synonyms: Protein IWS1 homolog|IWS1-like protein|IWS1|IWS1L

Background: Transcription factor which plays a key role in defining the composition of the RNA polymerase II(RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Molecular Weight: 116-120 kDa

Gene ID: 55677

UniProt: Q96ST2